Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism
نویسندگان
چکیده
منابع مشابه
hypoglycemia in sick preterm infants and the therapeutic effect of 12.5% dextrose in water compared with 10% dextrose in water
neonatal hypoglycemia is common and its prompt management is important to reduce neurological sequelae. to determine the effect of two different glucose concentrations of intravenous (iv) fluid therapy in the incidence of hypoglycemia in sick premature infants, 200 preterm infants weighing 1500-2500 g were selected and randomly assigned into two groups. group 1 received 10% dextrose in wate...
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متن کامل[Congenital hyperinsulinism].
In the last five years, our knowledge about the heterogenous syndrome of congenital hyperinsulinism (HI) has expanded explosively. HI may be familiar or sporadic, mild or severe, transitory or persistent, and histologically focal or diffuse. At least 63 disease-causing mutations have been found in the genes for the beta cell's ATP-dependent potassium channel, whose elements are the sulphonylure...
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INTRODUCTION Congenital hyperinsulinism is a rare inherited disease caused by mutations in genes responsible for β-cell's function in glucose hemostasis leading to profound and recurrent hypoglycemia. The incidence of the disease is about 1 in 50000 newborns. Mutations in at least 8 genes have been reported to cause congenital hyperinsulinism. Mutations in ABCC8 gene are the most common cause o...
متن کاملNovel Hypoglycemia Phenotype in Congenital Hyperinsulinism Due to Dominant Mutations of Uncoupling Protein 2.
Context The rarest genetic form of congenital hyperinsulinism (HI) has been associated with dominant inactivating mutations in uncoupling protein 2 (UCP2), a mitochondrial inner membrane carrier that modulates oxidation of glucose vs amino acids. Objective To evaluate the frequency of UCP2 mutations in children with HI and phenotypic features of this form of HI. Design We examined 211 child...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2018
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000491105